Date
September 28, 2021 - 9:00amEvent Description
Presenter: Dr. Lillian Tran (advisors: Drs. Angus Thomson & Abhinav Humar)
Successful tolerance induction using immune cell-based therapies in transplantation depends on understanding of the peripheral circulating and local intra-graft immune cellular milieu that underlie graft injury and survival. In an ongoing phase I/II clinical study assessing regulatory dendritic cell (DCreg) therapy in liver transplantation, peripheral blood and liver allograft tissue samples were obtained from liver transplant recipients at multiple timepoints prior to and after liver transplantation. Serum plasma protein and liver tissue single cell transcriptomic analysis were performed to compared changes in the immune cell compartments in liver transplant recipients who received DCreg therapy to matched control patients. We will additionally present preliminary single cell transcriptomic data from liver transplant mouse models to characterize early post-transplant immune cell infiltration into liver allograft and how they contribute to hepatic ischemic-reperfusion injury in the setting of transplantation.
Location and Address
MS Teams virtual meeting
Meeting logon info has been emailed to Department of Surgery staff. For Pitt and UPMC staff outside the department who wish to access the lecture, please email surgerywebmaster@upmc.edu. This presentation will be recorded and access to the recording can be obtained by contacting mrr18@pitt.edu.