A Computational Analysis of Dynamic, Multi-Organ Inflammation induced by Endotoxin in Mice

Presenter: Dr. Ruben Zamora

Dr. Zamora is a Research Professor of Surgery at the University of Pittsburgh, and a long-term collaborator of Dr. Vodovotz. Their research team employs computational and systems biology approaches to inflammation in multiple disease states (sepsis/trauma, wound healing, chronic inflammatory diseases, and cancer), coupled to biochemical, cellular, animal, and clinical studies, with the goal of rational inflammation reprogramming.

Recent relevant publications

• Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes
• Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure
• Analysis of the Plasma Metabolome after Trauma, Novel Circulating Sphingolipid Signatures, and In-Hospital Outcomes
• IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis
• Early Dynamic Orchestration of Immunologic Mediators Identifies Multiply Injured Patients who are Tolerant or Sensitive to Hemorrhage
• Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma
• MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes
• Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro