Date
April 8, 2021 - 8:30amEvent Description
Presenter: Dr. Hülya Bayir
Dr. Bayır is an expert in the area of acute brain injury with a special emphasis in novel diagnostic and therapeutic approaches targeting oxidant derived cellular damage. She has pioneered new methodologies related to the application of oxidative lipidomics to both in vitro and in vivo experimental models and in human brain injury. Her work has provided fundamental insights into the link between oxidative stress, mitochondrial injury and neuronal cell death. In this talk, Dr Bayir will tell us about oxidized phospholipid signals in apoptosis and ferroptosis, label free imaging of phospholipids and their oxidized forms in cells and tissues using imaging mass spectrometry and clinical lipidomics.
Background reading:
- Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury
- Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
- PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals
- Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spec-trometry (GCIB-SIMS)
Location and Address
Zoom virtual meeting
Zoom meeting logon info has been emailed to Department of Surgery staff. For Pitt and UPMC staff outside the department who wish to access the lecture, please email surgerywebmaster@upmc.edu.