Markers of Inflammation and Endothelial Damage are Differentially Expressed in Trauma Patients Following Prehospital Plasma Fluid Resuscitation

Presenter: Danielle Gruen, PhD (advisors: Drs. Jason Sperry & Timothy Billiar)

In the PAMPer trial, early, prehospital plasma fluid resuscitation following severe trauma in patients at risk for hemorrhagic shock was shown to significantly reduce 30 day mortality. However, the biological mechanisms conferring a survival benefit to this patient population are uncertain, making it challenging to identify patients who are at the greatest risk of death and to target those who would have the greatest benefit from novel interventions. In this talk, Dr. Gruen will present markers of inflammation and endothelial damage measured in the PAMPer patients. By using clustering techniques and regression analyses, she will explain possible mechanisms for the observed survival benefit. Finally, Dr. Gruen will explain how this could help us to understand why some sets of patients may appear to be more responsive to prehospital plasma.