Date
January 14, 2021 - 8:30amEvent Description
Presenter: Dr. Ryan McEnaney
Dr. McEnaney's lab studies the processes involved in arteriogenesis. When a large artery becomes occluded, hemodynamic changes stimulate remodeling of arterial networks to form collateral pathways in a process termed arteriogenesis. Prior reports have shown that a developing collateral artery may increase its diameter 10-20 times during arteriogenesis, and increase its cellular mass up to 50-fold. It also has been observed that the internal elastic lamina becomes fragmented and even transiently disappears in these expanding vessels. While it may be intuitive that the ECM must be altered to permit arterial diameter expansion, the nature of this restructuring has not been characterized. He will discuss his lab’s investigation into the ECM changes occurring among collateral arteries of different sizes using a modified animal model of hindlimb ischemia.
Background Publications:
- A modified rat model of hindlimb ischemia for augmentation and functional measurement of arteriogenesis
- Recruitment and maturation of the coronary collateral circulation: Current understanding and perspectives in arteriogenesis
Location and Address
Zoom virtual meeting
Zoom meeting logon info has been emailed to Department of Surgery staff. For Pitt and UPMC staff outside the department who wish to access the lecture, please email surgerywebmaster@upmc.edu.