Date
December 3, 2020 - 8:30amEvent Description
Presenter: Dr. Matthew Neal
Dr. Neal's lab focuses on mechanisms of thrombosis and coagulopathy, especially after surgery and trauma. Recently he has become interested in immunothrombosis in a variety of pathologies, and is now helping lead a clinical trial investigating thrombotic aspects of COVID-19 disease. He will talk about these investigations in his talk.
For background, here are some recent publications about immunothrombosis in COVID-19:
- Immunothrombosis and thromboinflammation in host defense and disease. Martinod K, Deppermann C. Platelets. 2020 Sep 8:1-11. doi: 10.1080/09537104.2020.1817360. Online ahead of print. PMID: 32896192
- Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis. Skendros P, Mitsios A, Chrysanthopoulou A, Mastellos DC, Metallidis S, Rafailidis P, Ntinopoulou M, Sertaridou E, Tsironidou V, Tsigalou C, Tektonidou M, Konstantinidis T, Papagoras C, Mitroulis I, Germanidis G, Lambris JD, Ritis K. J Clin Invest. 2020 Nov 2;130(11):6151-6157. doi: 10.1172/JCI141374. PMID: 32759504
- Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19. Hottz ED, Azevedo-Quintanilha IG, Palhinha L, Teixeira L, Barreto EA, Pão CRR, Righy C, Franco S, Souza TML, Kurtz P, Bozza FA, Bozza PT. Blood. 2020 Sep 10;136(11):1330-1341. doi: 10.1182/blood.2020007252. PMID: 32678428
Location and Address
Zoom virtual meeting
Zoom meeting logon info has been emailed to Department of Surgery staff. For Pitt and UPMC staff outside the department who wish to access the lecture, please email surgerywebmaster@upmc.edu.