Development of Novel Ambulatory Pulmonary Assist System (Update) / Waste Not, Want Not: An In Vitro Evaluation of Novel Plasma Supernatants Produced from Late-Storage Low-Titer Type

"Development of Novel Ambulatory Pulmonary Assist System (Update)"

Presenter: Yeahwa Hong, MD (mentors: Keith Cook, PhD, and Dr. David Kaczorowski, MD)

"Waste Not, Want Not: An In Vitro Evaluation of Novel Plasma Supernatants Produced from Late-Storage Low-Titer Type"

Presenter: Amudan (Jay)  Srinivasan, MD (mentors: Matthew Neal, MD, and Susan Shea, PhD)

Low-titer type O whole blood (LTOWB) is increasingly being used for first-line resuscitation in the setting of civilian traumatic hemorrhage. Current US regulations limit LTOWB storage in citrate-phosphate-dextrose to 21 days. If unused before day 21, LTOWB units can be manufactured into red cell units, and the plasma supernatant typically discarded. However, this plasma supernatant may have value as a novel transfusion product. This talk will discuss an ongoing comprehensive in vitro evaluation of the hemostatic properties of these products.