Donor Extracellular Vesicles Trigger B-cell Allorecognition in Transplantation
Presenter: Dr. Adrian Morelli, Starzl Transplant Institute
Simmons Research Conferences
Matrix Bound Nanovesicles: The Next Generation of ECM-based Biomaterials?
Presenter: Dr. George Hussey
Dr. Hussey's research interests include determination of an in-depth understanding of the molecular mechanisms of matrix-induced constructive remodeling and immune modulation, with the broad goal of identifying and characterizing molecular targets to bias these responses. His talk will highlight the recent discovery of matrix bound nanovesicles, and how utilization of this ECM-based nanotherapy will allow us to target therapeutic applications previously untenable for planar ECM bioscaffolds.
Investigating the Role of Metformin in Improving Immune Defects Associated with Aging/Engineering Improvements in Vascular Graft Patency
"Investigating the Role of Metformin in Improving Immune Defects Associated with Aging"
Presenter: Maryam Mohammed, MD (advisor: Brian Zuckerbraun, MD)
"Engineering Improvements in Vascular Graft Patency"
Presenter: JB Moses, MD (advisor: Edith Tzeng, MD)
Environmental/Epigenetic Variables Affecting Expression of von Hippel-Lindau Disease & Inflammatory & Endothelial Damage Markers in Trauma Patients Receiving Prehospital TXA/Role of Circadian Rhythm Genes & Potential Therapeutic Role of Blue Light in IBD
"The Role of Circadian Rhythm Genes & Potential Therapeutic Role of Blue Light in Inflammatory Bowel Disease"
Presenter: Katherine Hrebinko, MD (advisor: Kevin P. Mollen, MD)
Bone Marrow and Megakaryocyte Biology in the Context of the Immune Response to Trauma and Multiple Organ Dysfunction Syndrome / Investigating Circadian Control of Fibrinolysis and Subsequent Venous Thrombosis
"Bone Marrow and Megakaryocyte Biology in the Context of the Immune Response to Trauma and Multiple Organ Dysfunction Syndrome"
Presenter: Jillian Bonaroti, MD (advisors: Timothy Billiar, MD / Matthew Neal, MD)
Promoting immune tolerance through regulatory dendritic cell (DCreg) infusion in living donor liver transplantation
Presenter: Lillian Tran, MD (advisors: Drs. Abhinav Humar and Angus W. Thomson)
In this follow-up presentation, Dr. Tran will describe her work integrating early clinical outcomes and mechanistic findings in a phase I/IIa clinical trial.
Patterns of Interhospital Transfer in Emergency General Surgery
Presenter: Cindy Teng, MD (Advisors: Drs. Matthew Rosengart / Jeremy Kahn)
cGAS is Critical in Maintaining the Crosstalk Between Cell Death and Autophagy during Intestinal Inflammation
Presenter: Sidrah Khan
Dr. Khan will first provide a background of inflammatory bowel disease (IBD). She will then discuss the role of cGAS (cycline GMP-AMP synthase) in inflammation and cell death in the context of the biological mechanisms of autophagy and mitophagy in IBD. She will then present early findings of the role of downstream signaling effector stimulator of interferon genes (STING) in her evolving paradigm of the biology of IBD.
The Role of NETs in the Perioperative Tumor Microenvironment
Presenter: Christof Kaltenmeier (advisors: Dr. Samer Tohme)